Dybala, a half-time substitute for the Giallorossi, capped off a night that also saw him presented with a special gift from the club in recognition of his World Cup success by scoring the winning goal - wriggling free of his markers with just 20 minutes gone in the second half before lashing home from inside the box.
Jose Mourinho's side had plenty of chances to break the deadlock prior to that, with Lorenzo Pellegrini hitting the crossbar and Tammy Abraham and Marash Kumbulla both forcing good saves from the Genoa goalkeeper.
Once they went behind the Serie B side understandably pushed forward in search of an equaliser, only to be thwarted at every turn.
Roma will face either Napoli or Cremonese in the quarter-finals, with that match set to take place in the first week of February.
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