The Giallorossi romped to victory under the watchful eyes of both Jose Mourinho and Tiago Pinto at Stadio Tre Fontane, extending their advantage over their nearest challengers in the fledgling league standings.
Federico Guidi's side went behind early on and were also briefly pegged back at 2-2 having taken the lead, but a dominant finish to the game ensured they walked away with the three points.
Antonio Satriano (2), Claudio Cassano, Luigi Cherubini and Riccardo Pagano scored the goals for Guidi's team.
"I am really pleased with the what the lads have done today, especially considering the opposition drew with Paris Saint-Germain [in the UEFA Youth League] recently," the coach said.
"The scoreline is the reward for a top-quality display, with a lot of players performing really well.
"There is still a long way for us to go, this was just another step on the path for us - but we took that step really well."
Roma now sit on 29 points from the opening 12 games over the season, five clear of the Bianconeri in second play.
See photos from Saturday's match in the gallery below!
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