The Giallorossi will once again enter the tournament at the last-16 stage, which is scheduled to take place in mid-January.
Spezia and Bologna are the Serie A sides that will be vying to meet Paulo Fonseca's team at that stage of the competition.
The Giallorossi could then face Napoli in the quarter-finals, while Atalanta and Lazio are the two notable potential semi-final threats.
Juventus, Inter Milan and AC Milan are all on the other side of the draw, and can only face Roma in the final of this season's competition - which will take place on 19 May 2021.
See the complete knockout tree for the competition in the graphic below.
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