Milena Bertolini's side made it six wins from six in qualification for the 2021 European Championship - as Greggi scored her first-ever goal for her country.
Giugliano got on the scoresheet in the first half with a left-footed strike from distance, although she later received her marching orders after picking up two yellow cards.
Greggi came on as a second-half substitute, finding the back of the net in injury time to make her second appearance for the Azzurre one she will never forget.
Roma captain Elisa Bartoli once again started the match, although she was substituted at half-time.
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