Roma have won 52 of the 146 previous meetings between the two sides in Serie A: Napoli have won 43, with the other 51 games (unsurprisingly) having finished as draws.
The last meeting between these two sides, back in March last season, was also the last time the Giallorossi came back from a goal behind to win in Serie A. On that occasion the Giallorossi ran out 4-2 winners.
Roma have won the last two games at the San Paolo between these two sides - having previously lost three of the last four at the ground (one draw).
Roma have had more different goalscorers (11) than any other side in Serie A so far this season.
The Giallorossi have also put more of their shots on target than any other side - 54% of the team's attempts have tested the goalkeeper.
Edin Dzeko has scored four goals against Napoli in Serie A - making them his most common victim in the Italian top flight.
Carlo Ancelotti has come up against his old club on 31 occasions as a manager. Of those, Ancelotti has enjoyed 11 wins, come away with 11 draws and suffered nine defeats. The last time he was in the dugout against the Giallorossi was in May 2009, as Roma beat AC Milan 3-2.
Daniele De Rossi's next appearance in Serie A will be his 450th.
The San Paolo was the site of Stephan El Shaarawy's first ever away brace in Serie A, back when he was playing for AC Milan in November 2012.
In 20 appearances against AC Milan during his career, Napoli midfielder Marek Hamsik has scored five goals and provided four assists.
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