Thomas Vermaelen returns to the matchday squad after injury - but Stephan El Shaarawy misses out.
The game kicks off at 21:05 CET.
See the full squad list below.
Roma squad list to face Viktoria Plzen:
Alisson Becker
Lorenzo Crisanto
Wojciech Szczesny
Kostas Manolas
Emerson Palmieri
Federico Fazio
Moustapha Seck
Thomas Vermaelen
Bruno Peres
Juan Jesus
Antonio Rudiger
Gerson
Daniele De Rossi
Kevin Strootman
Leandro Paredes
Radja Nainggolan
Diego Perotti
Mohamed Salah
Edin Dzeko
Juan Manuel Iturbe
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