Tammy Abraham provided both assists for his World Cup-winning teammate, as the visitors struggled through much of the match with only 10 men.
An early red card for defender Dodo set the tone for Vincenzo Italiano's side, as Dybala punished them soon after with a fine first-time finish from Abraham's knock-down.
It took until the final 10 minutes for the Giallorossi to kill the game off, however, as Abraham slid an inviting pass into the box that Dybala simply had to tap home.
Jose Mourinho's side now have two away games in succession; next week they travel to Liguria to take on Spezia on Sunday.
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