The Giallorossi could yet finish fifth in the league, depending on Lazio's final result of the campaign, but will not finish any lower than sixth - meaning they will play in UEFA's second competition in 2022-23.
It will be the club's ninth straight season of European football.
Jose Mourinho's side still have one more game to go this season; they face Feyenoord in the final of the inaugural Europa Conference League on Wednesday 25 May.
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