The two games against the Serie B side will take place over the last weekend of January and second week of February (final dates and times are still to be confirmed).
Alessandro Spugna's side will have the advantage of playing the second leg at home, at Stadio Tre Fontane.
Como reached this stage through a drawing a lots, progressing as the lucky losers after they finished level in all regards with Empoli and Napoli in Group B of the initial stage of the competition.
The winner of the tie will face either Fiorentina or Empoli in the semi-finals of the competition.
On the other side of the draw, Juventus will face Inter Milan while AC Milan go up against Sampdoria.
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