The Giallorossi's hopes of qualifying for the knockout phase of the competition were dealt a blow by Thuram's late header, after Federico Fazio had previously scored at both ends at Borussia-Park.
But Paulo Fonseca's side nevertheless remain in control of their destiny; wins in each of their final two group games will guarantee their place in the competition's last-32.
In front of a sold-out crowd in Gladbach the visitors started slowly, but were nevertheless well in the contest prior to Fazio's unfortunate own goal as he stretched to reach Thuram's low cross - an intervention which proved the difference at the break.
The defender made amends in the second half with a similar finish as he latched onto Javier Pastore's cross - only for Thuram to steal the show in the dying moments.
Roma next travel to face group leaders Istanbul Basaksehir at the end of the month. Their final group game sees them host Wolfsberg at the Stadio Olimpico.
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