The game at the Stadio Olimpico gets underway at 21:00 CEST.
Reasons to be optimistic
Roma have only faced Frosinone twice in Serie A: winning on both occasions, scoring five goals and conceding just one.
El Shaarawy's instant impact
Back in January 2016, Stephan El Shaarawy made his Roma debut at home against Frosinone - scoring an incredible backheel strike to help drive the Giallorossi to a 3-1 win.
Tough times on the road...
Frosinone have won just two of their 21 away trips in Serie A to date, drawing three and losing the other 16.
Goals spread out...
Roma have had more different goalscorers than any other side so far this season - the side's seven goals have been converted by seven different goalscorers.
Dzeko and Flo
Gli Two Roma players have been involved in more than one goal so far this season: Edin Dzeko (one goal, two assists) and Alessandro Florenzi (one goal, one assist).
Rotation goals
Frosinone have used more different players than any other club so far this season - 23 players have already taken the field for the Gialloblu.
Second half blues
10 of the 12 goals Frosinone have conceded this season have arrived in the second half - including both against Juventus at the weekend. It is the worst second half record of any side so far this season.
Toothless in front of goal
Frosinone are still to find the back of the net this season: not since the 1998-99 campaign has a side failed to score in any of their first five league games (Venezia, who managed to stay up that season in the end anyway).
Ciano the main man in attack
Camillo Ciano has been involved in more shots for Frosinone than any other player - taking 10 shots and providing a further six final passes for subsequent shots on goal.
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