The Giallorossi have 11 points and are already assured of topping the group, while Astra (7) are two clear of third-placed Austria Wien - and so still have everything to play for in the final reckoning.
Here's 11 facts and figures ahead of tomorrow evening's match at Bucharest's national stadium...
The reverse fixture - which ended 4-0 to Roma - is the only previous meeting between the two sides. The Giallorossi have only lost once against Romanian opposition, winning on four occasions.
The Romanian side are yet to keep a clean sheet in the Europa League this term and have conceded on average two goals per match.
Roma have the second best frontline in the competition with 16 goals for, one fewer than Shakhtar Donetsk. Half of those strikes have come in the opening 45 minutes, a record no other side can beat.
Francesco Totti has laid on four goals in this Europa League campaign. Only Zenit St Petersburg's Giuliano (5) has more.
The Giallorossi are unbeaten in their last five games on the continent (three wins, two draws), their best run since December 2009 (four wins, one draw).
Before playing Astra Giurgiu, Roma had come up against Romanian opposition six times in Europe. The Giallorossi met Steaua Bucharest in 1984 in the last-32 of the Cup Winners' Cup and Cluj twice in the space of three seasons - in the 2008-09 and 2010-11 Champions League group stages. Roma's record stands at three wins, two draws and one defeat with eight goals for and five against.
Roma, already sure of top spot, have qualified for the knockout stages in eight of their last nine European campaigns, only missing out in the 2014-15 edition of the Champions League.
Edin Dzeko has struck 17 goals in 20 matches this season in all competitions, more than anyone else at a Serie A club (Mauro Icardi is chasing him on 14).
Roma's record in the Europa League is as follows: played 23, won 11, drawn 7, lost 5, for 55, against 32.
The Giallorossi's 33 shots on target is a season high in the Europa League.
Thursday sees a meeting of the team with the second highest ball possession percentage (Roma, 63%) and the side with the lowest average in the competition (Astra Giurgiu, 35%).
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