The game at the Giuseppe Meazza gets underway at 20:45 CEST.
Kevin Strootman and Antonio Rudiger are both suspended for the game.
See the full squad list below.
AS Roma squad to face AC Milan:
Alisson Becker
Bogdan Lobont
Wojciech Szczesny
Konstantinos Manolas
Emerson Palmieri
Mario Rui
Federico Fazio
Thomas Vermaelen
Bruno Peres
Juan Jesus
Gerson
Daniele De Rossi
Diego Perotti
Clement Grenier
Radja Nainggolan
Leandro Paredes
Stephan El Shaarawy
Mohamed Salah
Edin Dzeko
Francesco Totti
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