With Daniele De Rossi rested at the Estadio Metropolitano, Nainggolan will lead the side out for the game - knowing a victory or draw will be enough to send the Giallorossi into the last-16 of the competition.
Elsewhere both Maxime Gonalons and Gerson start the game, while Bruno Peres slots in at right-back in the absence of Alessandro Florenzi.
See the full line-up in the graphic below.
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