Mkhitaryan leads the line against his old club, having scored a hat-trick against Genoa in his only other appearance without either Borja Mayoral or Edin Dzeko in the team with him.
Elsewhere, Chris Smalling drops to the bench as Marash Kumbulla comes into the defence - while Gonzalo Villar and Amadou Diawara partner together in central midfield.
See the full line-up in our graphic above.
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