Here are a few facts worth knowing about the contest, which gets underway at 21:45 local time.
The top flight precedents
These two sides have met 29 times to date in the Italian top flight, with Roma winning 20. Verona have been victorious on just two occasions, with seven draws.
The last time we lost...
You have to go back to the 1996-97 for that, a 2-1 defeat at the Bentegodi. Since then the Giallorossi have won 11 and drawn 5. For the last Verona win at the Olimpico you need to go all the way back to 1972-73, a 1-0 triumph.
The first double in Roma colours
This game will always have a place in the history books for that - as Enrico Cappa scored twice in a 2-1 win over Verona at the Motovelodromo Appio at the start of the 1927-28 season.
The traditional hitmen
Roberto Pruzzo (6) has scored more goals for Roma in this fixture than any other player, followed by Francesco Totti (5) and Gabriel Batistuta (4).
Of the current suspects
Edin Dzeko has scored two goals in his career against Verona; Cengiz Under, Justin Kluivert and Henrikh Mkhitaryan have also converted in this fixture.
Appearances made
Verona's most stable period in Serie A was in the 1970s and 80s, and that is reflected in the list of most appearances made against them by Roma players. Sergio Santarini leads the way with 20, Franco Tancredi sits second on 19, and Sebino Nela and Roberto Pruzzo share the bronze medal spot with 16.
A fourth meeting with Juric
Roma have won each of their last three meetings with Ivan Juric, including at the start of this season (a 3-1 win up north). The other meetings came in 2016-17, when Juric was the Genoa coach, as Roma won 1-0 at the Marassi and 3-2 - in Francesco Totti's final game for the club - at the Olimpico on the final day.
The Giallorossi against the newly promoted
So far this season the Giallorossi have gone five for five in games against the newly-promoted sides - a win on Wednesday would complete the set. In fact, it would be the third straight season the Giallorossi have picked up maximum points against the Serie A new boy.
Micki factor
Since February no Roma player has played a part in more goals than Henrikh Mkhitaryan: Eight in just nine appearances (five goals, three assists).
Dzeko debut
Dzeko's first game for Roma came against Verona at the Bentegodi, back in August 2015. In four games since that match he has scored two goals against the Gialloblu and provided one assist.
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