Coach Paulo Fonseca has named both men among his travelling party for the match at the Stadio San Paolo, which gets underway at 21:45 local time.
It is the first time Zaniolo has been involved in the squad since suffering a serious knee injury in a game against Juventus in January.
Lorenzo Pellegrini and Jordan Veretout also both return after suspension.
See the full squad in the graphic above!
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