The game gets underway at 15:00 local time, with both sides looking to build on solid starts to the new Serie A season.
Here are the facts you need to know ahead of the clash...
Six years…
Despite a few ups and downs in recent seasons, Roma are actually unbeaten in their last 10 meetings with Cagliari - winning seven and drawing three of those games. The last time the Sardinian side won in this fixture was back in February 2013.
…and no goals
In fact, Cagliari's last goal at the Olimpico against Roma came during that 2013 win - the Giallorossi have kept five clean sheets in succession since that game.
Unbeaten run
Cagliari are unbeaten in their last four games in Serie A - three wins, one draw - which is their longest such run since December 2018. It was back in 2014 that the club set their record in Serie A; seven games unbeaten.
Winning on the road
For the first time since 2013, Cagliari have won back-to-back away games in Serie A. The last time they reached three in a row was 1992.
First half flyer
No side has scored more goals than Roma in the first half of games so far this season - seven. But only Inter (0) have conceded fewer first half goals than Cagliari (1) up to this point...
Heads up
Cagliari have scored four goals from headers already this season, the best record of any team in Serie A.
Pastore's last goal
Javier Pastore's last Serie A goal came against Cagliari in this fixture back in April. It was the Argentine's second career goal against Cagliari: he also scored against them while with Palermo in 2011.
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