The Czech Republic international will lead the line alone for Eusebio Di Francesco's side for the first time this season, with Edin Dzeko on the substitutes' bench.
Elsewhere, Justin Kluivert starts once again after his fine performance against CSKA Moscow in midweek - as Stephan El Shaarawy returns to the starting XI.
Alessandro Florenzi once again captains the side in the absence of Daniele De Rossi.
See the full line-up in the graphic below.
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