The midfielder was substituted off after 79 minutes - replaced by Jordy Clasie - as his side secured an important three points.
There was also good news for Kostas Manolas, who played the full 90 minutes as Greece beat Cyprus 2-0.
Elsewhere there was disappointment for Edin Dzeko, whose Bosnia & Herzegovina side lost 4-0 away to Belgium. Dzeko played the full 90 minutes.
Goalkeeper Alisson also played 90 minutes in Brazil's emphatic 5-0 win over Bolivia.
Wojciech Szczesny and Poland are in action against Denmark on Saturday, while on Sunday it is the turn of Mohamed Salah and Egypt, as they face Congo.
Azzurri duo Daniele De Rossi and Alessandro Florenzi are also in action again next week against Macedonia, following the recent 1-1 draw with Spain.
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