With both Bruno Peres and Kevin Strootman missing the trip, Spalletti has returned Alessandro Florenzi to right-back and installed Paredes in midfield alongside Daniele De Rossi and Radja Nainggolan - who scored the winner the last time the two sides met in April last season.
Diego Perotti, Mohamed Salah and Edin Dzeko complete Spalletti's strikeforce.
See the full lineup in the graphic below.
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