With Alessandro Florenzi the club's only ongoing injury absentee the coach has named a strong squad for the contest - with Juan Jesus (suspended) and Mohamed Salah (international duty) the only notable absentees.
Primavera players Marco Tumminello and Luca Pellegrini have also been included.
The game at the Stadio Olimpico gets underway at 20:45 CET.
Roma squad list to face Cagliari:
Alisson Becker
Bogdan Lobont
Wojciech Szczesny
Luca Pellegrini
Kostas Manolas
Emerson Palmieri
Mario Rui
Federico Fazio
Moustapha Seck
Bruno Peres
Antonio Rudiger
Thomas Vermaelen
Daniele De Rossi
Gerson
Leandro Paredes
Kevin Strootman
Radja Nainggolan
Diego Perotti
Stephan El Shaarawy
Francesco Totti
Edin Dzeko
Marco Tumminello
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