Both Radja Nainggolan and Diego Perotti are fit and available for the game despite picking up knocks in last week's win over AC Milan - while Primavera youngsters Davide Frattesi and Marco Tumminello have also been called up for the game.
Top goalscorer Edin Dzeko misses the match due to injury, while Kevin Strootman is suspended.
The match at the Stadio Olimpico gets underway at 20:45 CEST.
AS Roma squad to face Juventus:
Alisson Becker
Bogdan Lobont
Wojciech Szczesny
Konstantinos Manolas
Emerson Palmieri
Mario Rui
Federico Fazio
Thomas Vermaelen
Bruno Peres
Juan Jesus
Antonio Rudiger
Davide Frattesi
Gerson
Daniele De Rossi
Diego Perotti
Clement Grenier
Radja Nainggolan
Leandro Paredes
Stephan El Shaarawy
Mohamed Salah
Francesco Totti
Marco Tumminello
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