The midfielder has been named in the starting line-up for the game by coach Eusebio Di Francesco - who himself is going up against his old club for the first time.
Elsewhere, Edin Dzeko starts in attack, alongside Patrik Schick and Diego Perotti.
In defence, Alessandro Florenzi will make his 200th appearance for the club.
See the full line-up in the graphic below.
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