The Belgian midfielder picked up two yellow cards - perhaps somewhat harshly - midway through the second half, a turning point in the game - and one that effectively took the sting out of it.
Up until that point Roma had created the better of the chances - but a crucial goal proved elusive throughout.
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The result meant that Juventus mathmatically clinched the Serie A title, while Roma still need to get a positive result against Sassuolo next weekend to be guaranteed third.
Di Francesco opted for Lorenzo Pellegrini in midfield alongside Daniele De Rossi and Radja Nainggolan, despite the return to availability of Kevin Strootman.
Diego Perotti was also on the bench, as Cengiz Under, Stephan El Shaarawy and Edin Dzeko continued in attack.
8' - First opening for the home side! Pellegrini plays in Dzeko, but the pass is fractionally behind the striker - who cannot steer his shot on target from 15 yards out!
10' - CLOSE! Radja wins the ball high up the pitch, bursts forward and fires narrowly over from the edge of the box!
26' - Double chance for Roma. Cengiz bursts forward and sees his powerful shot charged down inside the box. Moments later Pellegrini goes for the top corner from 20 yards, but is narrowly off target.
34' - Dybala fires low and wide from distance.
44' - Kolarov curls a free-kick from a tight angle into the side-netting.
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47' - Dybala is offside as he puts the ball in the net.
63' - Radja is booked for pulling back Alex Sandro.
65' - Kolarov pounces on a loose ball and hits a deflected drive that nearly loops over Szczesny and in!
68' - Red card. Radjais adjudged to have fouled Dybala on the edge of the box - and the referee shows him a second yellow card as a result.
85' - Important defensive intervention from Juan Jesus to prevent Dybala getting a clear sight of goal.
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"We were missing a little something extra at times up front, in the ability to create scoring opportunities in the league. We drew or lost sometimes because we were wasteful in the final third, but this isn't just down to the strikers: it was a problem for the whole team. Every one of us has to work on getting better in that respect."In order to win in the league you have to be perfect in every phase of play. Juve did that this year, playing well in attack and in defence. We have to continue on the road we're on, because we're headed in the right direction."
- Alisson Becker
"We're still growing as a side but I want to keep looking forward. We're building an identity, a sense of self as a team. We were able to carry Roma forward, in the league and in Europe too, by playing with our heads raised, without fear of our opponents. We can do great things with this sort of mentality."
- Eusebio Di Francesco
The Giallorossi have one final game in the 2017-18 campaign, as they travel to Sassuolo next Sunday. A draw will be enough for the team to clinch third in Serie A.
Red cards: Nainggolan (68')
Roma: Alisson; Florenzi, Fazio, Juan Jesus, Kolarov; Nainggolan, De Rossi, Pellegrini; El Shaarawy, Dzeko, Cengiz.
Juventus: Szczesny; De Sciglio, Barzagli, Rugani, Alex Sandro; Khedira, Pjanic; Bernardeschi, Dybala, Mandzukic; Higuain
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