The game at the Stadio Olimpico gets underway at 21:00 CEST.
Jose Mourinho has opted for an almost unchanged side from the first leg, which finished 1-1, as Nicolo Zaniolo and Tammy Abraham continue in attack.
Rick Karsdorp and Nicola Zalewski occupy the wide positions.
See the full line-up in the graphic below.
Leicester City, meanwhile, have made just two changes from the first leg - as Harvey Barnes comes into the attack in place of Marc Albrighton.
James Justin also replaces Timothy Castagne, but Kiernan Dewsbury-Hall and James Maddison continue in midfield.
The winner of Thursday's game - which could require penalties - will go on to the final, which takes place in Tirana, Albania on May 25.
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