Mattias Svanberg scored the only goal of the game midway through the first half, on a frustrating night for Jose Mourinho's side.
Tammy Abraham failed to convert with a number of good chances, as both he and Rick Karsdorp picked up yellow cards that will now see them miss Saturday's Serie A meeting with Inter Milan.
Stephan El Shaarawy also limped off injured, in a game where Lukasz Skorupski in the Bologna goal proved more than equal to anything thrown at him.
BOLOGNA 1-0 ROMA
SCORER: Svanberg (35')
BOLOGNA (3-4-2-1): Skorupski, Soumaoro, Medel, Theate; Skov Olsen (De Silvestri), Svanberg, Dominguez (Vignato), Hichey; Soriano, Barrow (Orsolini); Arnautovic (Sansone)
ROMA (3-5-2): Rui Patricio; Mancini (Vina), Smalling, Ibanez; Karsdorp, Veretout (Cristante), Diawara (Perez), Mkhitaryan, El Shaarawy (Shomurodov); Zaniolo, Abraham
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