Gianluca Mancini is drafted into defence and Davide Zappacosta comes in at right-back, as both summer arrivals make their first competitive start for the club.
Captain Alessandro Florenzi moves into a more attacking role, with Justin Kluivert dropping to the bench.
Lorenzo Pellegrini and Bryan Cristante once again partner each other in midfield.
The game at the Stadio Olimpico gets underway at 18:00 local time.
See the full line-up in our graphic.
UPDATE: Davide Zappacosta suffered an injury in the warm-up. His place in the starting line-up was taken by Justin Kluivert
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