Edin Dzeko, Nicolo Zaniolo and Cengiz Under all start - all three having signed new contracts with the club during the week.
Here's the full line-up for the game, which gets underway at 19:30 local time at the Stadio Citta di Arezzo.
ROMA XI to face Arezzo: Pau Lopez; Florenzi, Fazio, J. Jesus, Kolarov; Cristante, Diawara; Cengiz, Zaniolo, Perotti; Dzeko.
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