The match, Claudio Ranieri's first back in charge, gets underway at 20:30 local time.
The overall balance
There have been just 25 meetings between these two sides in Serie A. Roma have won 17 of those, losing just three.
The last nine
Roma are actually unbeaten in the last nine meetings between these two sides - with six wins and three draws in that span. The Giallorossi have not conceded a goal in the last three meetings.
Newly-promoted, usually beaten
With a victory on Monday night, Roma would set a new record for most consecutive victories against newly-promoted sides - 16.
El Sha vs Empoli
Stephan El Shaarawy has been involved in three goals in three games against Empoli in Serie A - scoring twice and adding a further assist. The Italian is also Roma's top goalscorer in Serie A this season, with eight goals.
Nzonzi's moment
Steven Nzonzi's first - and so far only - Serie A goal came in the corresponding fixture this season, as he broke the deadlock in Tuscany.
Edin on the run
Among all players in Europe's top five leagues who have scored at least five goals, Edin Dzeko is the only one who has scored all of them away from home (seven goals in total).
Ranieri's record in Serie A
Claudio Ranieri coached Roma once before, from 2009 until early 2011: in that period he oversaw 61 games. Of those, Ranieri won 35, drew 14 and lost 12. The Giallorossi scored 103 goals in total, conceding 71.
The coaches who came back
Claudio Ranieri is actually the 11 coach in Roma history to return to the club for a second period in charge. He joins the following list: Luigi Brunella, Guido Masetti, Gunnar Nordahl, Gyorgi Sarosi, Alfredo Foni, Naim Krieziu, Helenio Herrera, Nils Liedholm, Zdenek Zeman and Luciano Spalletti.
Roma goalscorers against Empoli
With five goals, Abel Balbo and Francesco Totti lead the all-time list of Roma goalscorers against Empoli, in both league and cup. The rest of the list: Edin Dzeko (3), Daniele De Rossi (2), Stephan El Shaarawy (2) and Steven Nzonzi (1).
Roma after a European night
So far this season, Roma have generally performed well in the league game following a Champions League night - with the exception being a 2-0 defeat against Bologna. Other than that, however, Roma have not been beaten - winning four and drawing the other two, the draws coming against Inter Milan and Napoli.
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