It was ultimately a frustrating afternoon for the Roma captain, who was forced off before half-time through injury as the Giallorossi were forced to settle for a 1-1 draw at the Stadio San Paolo.
De Rossi made his first Serie A appearance back in January 2003, in an away defeat against Como. Almost 19 years later, he reached 450 - all with the same club.
Seven other one-club players have made more Serie A appearances. Francesco Totti (619) is the only Roma player among that list.
AC Milan defender Paolo Maldini leads the all-time list, having made 647 appearances in the Italian top flight for the Rossoneri during his career.
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