The Germany international, who made a 12-minute cameo against Sassuolo in midweek after a four-month recovery from injury, goes straight into Luciano Spalletti's starting XI, with Alessandro Florenzi injured and Bruno Peres only considered fit for the bench.
Elsewhere it is the same XI that started at the Mapei Stadium - bar one switch in midfield, with Leandro Paredes coming in for Kevin Strootman.
See the full line-up in the graphic below.
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