A win for the Giallorossi in the Serie A finale will guarantee second in the Serie A standings, and with it automatic entry to next season's group stage.
After missing last weekend's win over Chievo Verona, Nainggolan returns to Spalletti's starting line-up, playing in behind Edin Dzeko - who will also be aiming to finish the season as the league's top goalscorer.
Daniele De Rossi captains the side. Francesco Totti starts among the substitutes.
See the full line-up in the graphic below.
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