Here are some dates for the diary - although please note that all dates listed are currently provisional, with kick-off times and dates still to be confirmed once broadcast and other requirements are considered.
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Mourinho's top-flight tenure with the Giallorossi begins on home soil as La Viola make the trip to the Stadio Olimpico on 22 August.
Recent history suggests this is an encouraging fixture for the Portuguese tactician to open his reign, with Roma winning each of the last four meetings between the two sides, and scoring 10 times in the process.
The trip to newly-promoted Salernitana a week later (29 August) is similarly promising, with Roma winning five of the six meetings between the two in Serie A, albeit this will be the first such fixture of this millennium.
The big one: the first Della derby Capitale of the campaign, and Mourinho's debut in the fixture promises to be some occasion.
Even more so when you factor in the possibility of the Olimpico welcoming fans back to the derby for the first time since January 2020's 1-1 draw between the two.
And Roma supporters should be highly encouraged by Mourinho's record against the other lot from Rome that reads; played four, won four, eight goals scored, none conceded.
Outside of the derby, October's trip to Turin looks like Roma's first major test of the Mourinho era and it kicks-off a tricky league run for the Giallorossi.
A week on from taking on the Old Lady of Italian football, Roma welcome Napoli to the capital for the Derby del Sole (24 October), before making the journey to Cagliari (27 October), and then tackling AC Milan (31 October).
That's four games in 15 days - in a period where the UEFA Conference League may also take place - with three of those against sides that finished in the top-five last time out.
'The Special One' is now a Romanista, but he remains a Nerazzurri legend and Inter's visit to Rome at the beginning of December offers Mourinho a first opportunity to get one over on his old club.
Serie A's current champions have a new head coach of their own in Simone Inzaghi, who will have some way to go in replicating the heroics of Mourinho at the San Siro - a place the Roma boss won two league titles, the Coppa Italia and the Champions League.
Mourinho has shown in the past he has little time for sentiment, and if anything will perhaps be even keener to get one over on the club where he achieved so much success.
Sampdoria at home on 22 December marks the final fixture of 2021, with Roma then back in action after the winter break with a trip to Inter's city rivals, Milan.
It's the opener in a bumper double-header, with Juventus travelling to Rome three days later (9 January). All in all, Mourinho and his team could hardly ask for a more action-packed start to the new calendar year.
The second Derby della Capitale of the season sees Roma in the home dressing room this time around and that could be a good omen for the yellow and red half of the city.
The Giallorossi are unbeaten in four as the nominal league hosts (W3, D1) and have won five of the last 10 such Serie A fixtures, drawing three more times and losing just twice.
Following the final home game of the campaign against Venezia (15 May), Roma close out 2021-22 with a trip to Turin as they face Il Toro on 22 May.
Roma have beaten Torino more times than any other team in their Serie A history and - if they haven't already done so in the 28 November reverse - will be hoping to add to their 65 top-flight victories over Toro and end the season on a high.
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