The game will be held at Sassuolo's Mapei Stadium, with kick-off at 20:45 CEST.
It will be the first cup final in the history of the Giallorosse, three years after their formation.
The two sides played out a 0-0 draw last weekend in Serie A.
AC Milan currently sit in second in the table, while Betty Bavagnoli's side have recovered from a slow start to the campaign to sit fourth.
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