We've rounded up a few notable facts and figures ahead of the contest, which gets underway at 21:45 local time.
The most common foe
With 204 meetings to date (between the league, Coppa Italia and Europea competitions), Inter are the side Roma have played more than any other since the club's foundation in 1927. They are followed by Juventus (192) and AC Milan (189) in the standings.
The home record
Roma have hosted Inter a total of 88 times in the league to date, winning 36 of those. Inter have emerged victorious on 28 occasions, with the other 24 games (unsurprisingly) ending in draws.
Heading for 500
With a goalless draw at the San Siro earlier in the season, both sides remain on 499 total goals in this fixture. The next goal will be the 500th - the first time ever one match between two sides has reached that milestone.
Four on the spin
Roma and Inter have drawn each of their last four matches - never in their history has such a streak reached five.
Three is the magic number
After three defeats preceding it, Roma have now won three games in a row. Not since May 2018 have the Giallorossi managed to win four straight Serie A games.
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The top scorers in this fixture
Francesco Totti scored 12 goals against Inter during his career, surpassing Roberto Pruzzo's prior record of 10 against the Nerazzurri. Completing the top three are two other legends on eight: Amedeo Amadei and Pedro Manfredini.
Of the current crop
Edin Dzeko has scored twice to date against Inter for the Giallorossi. Of the rest of the squad, Diego Perotti, Cengiz Under and Aleksandar Kolarov have also all previously scored in this fixture.
Never before on this date
Sunday's match will be the first time ever Roma have played a competitive game on July 19.
99 in Serie A for Veretout
If he plays on Sunday, Jordan Veretout will make his 100th Serie A appearance as a professional.
Number 12 against Conte
Of the 11 previous Roma meetings with Antonio Conte the spoils have been split: four wins apiece, and three draws.
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