Ahead of the encounter, we've put together a few stats for you to pore over...
Inter have won their last two away games in Serie A but haven't won three consecutive league matches on the road since May 2015.
The Nerazzurri have emerged victorious from just two of their last 10 league fixtures against Roma, although both wins have come in the last three meetings between these sides (since 2015).
Ivan Perisic has three goals and an assist in his last seven Serie A appearances. He was also on the scoresheet against the Giallorossi at the Olimpico last season.
Roma have kept clean sheets in four of their last five home games in Serie A.
Inter have won more points (eight) from losing positions than any other Serie A side this term, recording two victories and two draws from the five games in which they have found themselves trailing.
Francesco Totti has played an active role in 10 Roma goals in his last 11 league matches, scoring six, including his 250th Serie A strike last week, and providing four assists.
Luciano Spalletti's side are unbeaten in their last 15 home games, with four draws and 11 wins (including the last six).
Luciano Spalletti has faced Inter 18 times in all competitions as Roma coach – 17 in his previous spell at the club and one since returning in January. His record reads W5, D6, L7.
Roma and Inter have met 166 times in Serie A, with the Nerazzurri triumphing 71 times compared to the Giallorossi's 47.
Roma's biggest win over Inter came in the 1941-42 season, the year of the club's first Scudetto. Goals by Miguel Angel Panto (two), Ermes Borsetti (two), Amedeo Amadei and Aristide Coscia helped the Giallorossi record a 6-0 drubbing.
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