Starting on the bench for the match in Russia, Moreno was pressed into action shortly after the half-hour mark as Carlos Salcido was forced off with an injury.
But El Tri were forced to reshuffle again midway through the second half, as Moreno was forced off himself with a knock. Rafael Marquez replaced him.
Mexico ultimately edged to a 2-1 victory thanks to Oribe Peralta's 72nd minute strike.
Juan Carlos Osorio's side have four points from their opening two games - and know a positive result against hosts Russia will send them into the semi-finals.
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