Defrel has been omitted from the squad for the final game of 2017, after coach Eusebio Di Francesco revealed on Friday that the forward had suffered a kick to the same knee he recently injured - a problem that would keep him out of the meeting with the Neroverdi.
Defrel's place in the squad is taken by Primavera forward Mirko Antonucci.
Saturday's game at the Stadio Olimpico gets underway at 15:00 CET.
See the full squad below.
Alisson Becker
Lukasz Skorupski
Bogdan Lobont
Juan Jesus
Aleksandar Kolarov
Hector Moreno
Federico Fazio
Bruno Peres
Emerson Palmieri
Kostas Manolas
Radja Nainggolan
Kevin Strootman
Lorenzo Pellegrini
Daniele De Rossi
Maxime Gonalons
Alessandro Florenzi
Gerson
Diego Perotti
Edin Dzeko
Patrik Schick
Cengiz Under
Mirko Antonucci
Stephan El Shaarawy
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