Trailing 4-1 from the first leg of the double-header - which Manolas missed due to suspension - the return of the Roma defender stabilised the Greek defence, but they were unable to make an impression going forward as a 0-0 draw in Piraeus in the second leg was the best they could muster.
The play-off ties continue on Monday, with Italy also looking to overturn a first-leg deficit as they host Sweden in Milan. Daniele De Rossi, Stephan El Shaarawy and Alessandro Florenzi could all be involved.
The likes of Cengiz Under, Hector Moreno and Lukasz Skorupski could also be in action for their countries in friendly matches around the globe.
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