The Turkish winger will remain at home to continue his recovery from a slight muscle issue - with his condition being evaluated on a daily basis ahead of Wednesday's Champions League clash against Barcelona.
While Cengiz will not play at the Stadio Renato dall'Ara, both Luca Pellegrini and Gregoire Defrel will make the trip after overcoming recent injuries.
Lorenzo Pellegrini misses out.
Saturday's game at the Stadio Renato dall'Ara gets underway at 12:30 CEST.
See the full squad list below.
Alisson Becker
Bogdan Lobont
Lukasz Skorupski
Luca Pellegrini
Juan Jesus
Aleksandar Kolarov
Elio Capradossi
Federico Fazio
Alessandro Florenzi
Bruno Peres
Jonathan Silva
Kostas Manolas
Radja Nainggolan
Kevin Strootman
Daniele De Rossi
Maxime Gonalons
Gerson
Diego Perotti
Edin Dzeko
Patrik Schick
Gregoire Defrel
Stephan El Shaarawy
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