Patrik Schick led the line in attack in San Diego, with summer signings Bryan Cristante, Davide Santon, Antonio Mirante and Javier Pastore also all given the nod.
With Daniele De Rossi, Alessandro Florenzi and Kevin Strootman all starting the night on the bench, Manolas wore the captain's armband.
See the full line-up in the graphic below.
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