The game at the Stadio Olimpico gets underway at 15:00 CST.
Coach Luciano Spalletti said at his pre-match press conference that De Rossi's availability for the game would be assessed after Friday's training session - and the Italian has evidently been deemed fit to participate.
Full-back Emerson Palmieri misses out due to injury.
See the full squad below.
AS Roma squad to face Atalanta:
Alisson Becker
Bogdan Lobont
Wojciech Szczesny
Kostas Manolas
Mário Rui
Federico Fazio
Thomas Vermaelen
Bruno Peres
Juan Jesus
Antonio Rudiger
Gerson
Daniele De Rossi
Diego Perotti
Kevin Strootman
Clement Grenier
Leandro Paredes
Radja Nainggolan
Mohamed Salah
Stephan El Shaarawy
Francesco Totti
Edin Dzeko
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